OxyGenesis

A super-refined revitalising treatment, that combines in a single session cutting edge technologies aiming to regenerate, infuse and hydrate the entire face and neck area.

Step 1

Lasergenesis

A laser-induced rejuvenation process leverages rays of powerful energy to treat deeper layers of the skin without harming the overlying epidermis. By stimulating fibroblast activity and boosting their metabolism an immediate skin remodelling is achieved resulting in improved texture and overall radiance.

Step 2

Oxygen Infusion

During this ultra-hydrating treatment, high pressure hyperbaric oxygen is used to deliver hyaluronic acid and a powerful cocktail of vitamins, botanical peptides and antioxidants to the skin. Lightweight hyaluronic acid maximises dispersion of infused nutrients, helping reduce fine lines and wrinkles while improving texture and overall radiance.

Step 3

Photobionic waves

During the final stage of the treatment gentle waves will provide the skin cells with the energy to heal within. This phase of photobiostimulation functions as a meditation stage to the cells, supplying them with the energy to heal within and recover from the laser energy. The restoration phase not only accelerates the regenerative process but also provides an immediate glow to the face.

The regenerative effect of the OxyGenesis Facial will continue over several weeks, with recruitment of metabolically active cells and new collagen production.

HydraGenesis

An instantly revitalising facial booster that fuses hydradermabrasion, a noninvasive resurfacing technology, with a laser-induced rejuvenation process.

During the initial phase a cocktail of hyaluronic acid, vitamins and antioxidants are infused into the skin which has been cleansed through the vortex of water and natural exfoliants. The laser waves will then treat the deeper layers of the skin energising the fibroblasts, stimulating collagen production and helping to reverse damage inflicted to the face from ultraviolet radiation and ageing. The HydraGenesis is a skin saviour for patients with enlarged pores and congested, acne prone skin.

TRILOGY ENERGY LIFT

The Trilogy Energy Lift is a 3-step multi platform energy based facial that employs an innovative combination of hydraexfoliation, lasergenesis and radio frequency waves to address skin laxity on the eyelid, face and neck areas.

Over a course of four to six treatments, spaced two weeks apart, the treatment remodels the dermal layers of the face and neck by helping to stimulate new collagen growth.

The initial step of the Trilogy Lift fuses hydradermabrasion, a noninvasive resurfacing technology, with a laser-induced rejuvenation process. During this phase, a cocktail of hyaluronic acid, vitamins and antioxidants are infused into the skin which has been cleansed through the vortex of water and natural exfoliants. The laser waves will then treat the deeper layers of the skin energising the fibroblasts, stimulating collagen production and helping to reverse damage inflicted to the face from ultraviolet radiation and ageing.

Subsequently and during the core stage of the treatment, radio frequency waves will target the deeper dermal layers aiming to remodel laxity around the eyes and optimise the contour of the midface, jawline and neck areas.

The Trilogy Energy Lift is ideal for patients who are looking for discreet ways to refreshen their appearance and slow down the ageing process. Maintenance sessions every six months are recommended to optimise and maintain outcomes.

Illumino

A customised laser induced method formulated for cumulative environmental stress, skin inflammation, sun damage and rosacea-prone skin. Incorporating advanced light and laser therapies and a medical prescription regime, this treatment strengthens the skin, reduces inflammation, redness, pigmentation as well as helps desensitise skin to the triggers of inflammation.

This intensive facial treatment simultaneously prevents and corrects signs of ageing by combating free-radical damage and powering skin renewal.

Over the course of several treatments, newly produced collagen softens the appearance of wrinkles, pores, and textural irregularities.

This custom-created facial is suitable for all skin types and colours, and works effectively for both men and women.

Stage1

A multiple light wavelength energy targets damage inflicted from ultraviolet radiation, oxidative stress and ageing.

Stage 2

A laser induced rejuvenation process activates the metabolism of fibroblasts and enhances collagen regeneration.

Stage 3

High pressure hyperbaric oxygen that delivers hyaluronic acid and a powerful cocktail of vitamins, botanical peptides and anti oxidants to the skin.

Stage 4

Gentle waves on the red-infrared spectrum trigger a calming effect on the face providing the cells the energy to heal within.

E-LUMINANCE VASCULAR LASER

A process employing sophisticated laser platforms targeting the vascular plexus (veins and capillaries) in the upper and lower eyelid.

This plexus contributes to the dark hue of the eyelid skin and tends to become more prominent with age as a result of accumulative inflammation, weakening of the vascular wall tone, loss of skin elasticity as well as congenital and intrinsic biological factors.

By addressing and softening this area, you can reinstate skin clarity and improve dark circles and light reflection.

When combined with conservative lower eyelid volume restoration with hyaluronic gel fillers as well as energy-based devices it can have a transformative effect on the most expressive area of the face.

Triad

NYDG’s signature Triad Facial delivers the cosmetic boost of a facial with lasting dermatological benefits. Skin texture and tone are ostensibly improved, collagen production is boosted, and when undertaken regularly, the Triad Facial can help reverse damage inflicted on the face by acne, rosacea, UV radiation, and ageing.

Runway

Conceived by Dr David Colbert as the ultimate skin preparation for his A-list clients, The Runway Facial works to provide radiant camera-ready skin with zero downtime.

Combining advanced medical skincare technology (laser genesis, infrared waves, light waves and photobionic waves) with the cosmetic boost of a facial, the treatment aims to deliver immediate lifting, hydrating and skin-brightening effects. This is not a conventional facial, but a sophisticated skin-rejuvenating medical programme aimed at revitalising the entire face. All stages of skin remodelling are combined with Colbert

MD skincare products.

Lasergenesis

Laser Genesis is a non-invasive laser treatment designed to target fine lines, acne scars, large pores, and uneven skin tone by heating the upper dermis of your skin, which accelerates collagen regrowth.

Laser Genesis can be combined with other lasers, microneedling and injectables to improve skin texture and tone to rejuvenate the face (including the lips and area around the eye), neck, décolletage and hands. In the case of epidermal melasma, laser light facilitates the breakup of the superficial pigmentation and thus improve melasma and other forms of hyperpigmention.

Aquagold Infusion

A patented gold-plated infusion system that painlessly delivers customised solutions into the skin at the ideal depth of 600 microns. Aquagold is the new generation of micro channeling mesotherapy that can deliver nutritional ingredients into the dermis and stimulate cellular renewal in the upper layer of the skin.

Unlike conventional micro needling the treatment has no downtime and is suitable for the face, eyelids, neck, chest and back of the hands. Serial treatments can improve fine lines and wrinkles, enlarged pores and texture irregularities, boosting overall skin radiance. A series of 4 sessions is recommended for optimal outcomes.

SKINPEN

Collagen induction therapy is a minimally invasive skin-rejuvenation procedure that involves the use of an automated device to create a controlled channel through which cells are triggered to produce new collagen and elastin.

Through the resulting production of new collagen, there should be an improvement in skin texture and firmness, as well as a reduction in scars, pore size and stretch marks. The procedure has minimal downtime, and can be further personalised by combining trans-epidermal delivery of powerful antioxidants, peptides and nutrient serums. Some redness may occur immediately after treatment, which usually subsides by the next day

Exilis RF Waves

Exilis employs an innovative combination of ultrasound and radio frequency to address skin laxity as well as help reshape excessive fat deposits in the submental area.

Over a course of four treatments, spaced two weeks apart, the radio-frequency energy works to remodel the dermal layer of the skin by helping to stimulate new collagen growth. This can help to lift and tighten excess skin, making it ideal for redefining the facial contours and jawline. Maintenance sessions every six months are recommended to optimise and maintain results.

Titan Infrared Light Waves

The Titan infrared light waves treat loose, sagging skin anywhere on the body, including the face, neck, chin, jowls, stomach, arms, buttocks or thighs. The result of repeated (usually 2 or 3 Titan sessions spaced over six months) treatments is tighter, more toned and resilient skin and a ‘natural’ lift to the treated area. During the procedure, the Titan’s infrared light device, a laser wand, is passed over the area to be treated, delivering a series of quick pulses.

While the Titan handpiece cools the surface skin, the penetrating laser heat works to repair weak collagen fibers, which the natural aging process and environmental influences have worn down over time. In response to the Titan’s sub-dermal heat, new collagen begins to generate, in a sense called to action to repair the disturbed skin. Some improvement in skin tone and elasticity is immediately apparent, and time works to increase the effect. With further Titan treatments, the skin grows firmer and appears increasingly youthful and resilient.

Scar Remodelling

Biological therapies

Skin wound healing in humans, our body’s “glue” is a highly complex process requiring the collaborative efforts of many different tissues and cell lineages. With advances in the knowledge of wound healing, as well as the development of better materials and techniques, many options have become available in the treatment of patients with unsightly scars. Nevertheless, no technique has been devised to allow total and permanent removal or effacement of scars. Pharmacologic manipulation of the scar aims to alter cell metabolism at specific sites. Patients should understand that the goal of scar revision or remodeling is to improve the appearance and the acceptability of the scar.

Corticosteroids

For many years, intralesional corticosteroid injections have been established in the reduction of hypertrophic scars and keloids, alone or in combination with other therapeutic options. Corticosteroids are known primarily as gene regulators with anti-inflammatory effects. It is well known that inflammation related release of modulators plays a significant role in the rate and quality of wound healing

Steroids decrease fibroblast proliferation, reduce blood vessel formation, and interfere with fibrosis by inhibiting extracellular matrix protein gene expression: in specific they down regulates pro-alpha 1 collagen gene. By decreasing the production of collagen, dermal thickening is modulated and a smaller scar is created. The most commonly used preparations are Triamcinolone Acetonide (Kenalog) and Triamcinolone Diacetate (Aristocort) at a dose of 5 to 10mg/ml injected into the target area every 3 to 6 weeks.

Antimetabolites

Intralesional 5 Fluorouracil (5-FU) has been described as an effective treatment modality in the management of dermal scars, particularly for the treatment of hypertrophic scars, keloids and soft tissue retraction.

5 Fluorouracil is an anti-metabolite that inhibits cell proliferation through the disruption of DNA synthesis and inhibition of collagen production. 5-FU only works on cells that are metabolically active and proliferating, instead of causing collateral damage to surrounding cells. The main mechanism of action relies on inhibition of a key enzyme in the DNA synthesis process, named thymidilate synthetase and resulting in specific inhibition of proliferating and synthetically active cells that cause fibrosis. The relative specificity directed to actively synthetic or proliferating cells minimizes clinical tissue toxicity and side effects.

The efficacy of 5-FU in the management of scars may also be related to its capacity to interfere with transforming growth factor-b (TGF-b) and type I collagen gene expression in dermal fibroblasts. Abnormally excessive accumulation of type I collagen has been found in keloids and hypertrophic scars, which is believed to play a pathological role in these exuberant scar responses. TGF-b is though to be the main factor leading to tissue fibrosis secondary to its induction of collagen gene expression.

Cocktail injection

A combination of 5-FU with Triamcinolone acetonide and serial injections augment the modulation effect on the target zone and can prevent or ameliorate the scar. 5-FU acts on a slightly different pathway than steroids do, inhibits DNA production and decreases the proliferation of the infiltrating fibroblasts in the target area, ultimately lowering production of collagen and decreasing the density of the extracellular matrix.

Combining both agents in a 3:1 ratio (75% 5-FU 50 mg/ml and 25% Kenalog 5mg/ml) prompts a quicker resolution of the scar, allowing the inflammatory process and repair to continue without massive, or further, infiltration of fibroblasts. In addition by lowering the dose of steroids there is less incidence of fat atrophy or hypopigmentation. This approach can have a powerful effect especially in lower eyelid revision surgery as it can modulate the active status of fibroblasts in multi-operated and sensitive areas with pre-existing scarring.

FDA status and off-label use of anti-metabolites

5-Fluorouracil was approved by the Food and Drug Administration (FDA) for the treatment of various types of cancer. Upon approval, the drug manufacturer produces a “label” that explains its use. Once a drug is approved by the FDA, physicians can use it for other purposes “off-label” as part of the practice of medicine if they are well-informed about the product, base its use on firm scientific method and sound medical evidence, and maintain records of its use and effects.

The physician’s decision to use this agent is based on the evaluation of the advantages and potential disadvantages in each individual case. 5-FU has not received FDA approval for the treatment of scars although physicians have been using this drug off label for over a decade and several clinical studies have demonstrated its beneficial effect.

Exosomes

EXOSOMES AND EPIGENETIC SKIN REJUVENATION

Exosomes are key biological messengers that play a critical role to intercellular communication and cell biology.

These nanoscale vesicles, measuring just 30-200 nanometres are enveloped by a phospholipid bilayer membrane that protects their precious cargo: a cocktail of bioactive molecules that are critical for cell communication and repair.

Let’s think of them as the 5G signals of our bodies - packed with vital cellular information - incredibly efficient in delivering their contents to target cells with a mission to activate, support, and connect cells, ensuring the body operates as a synchronized system.

Because of their nanoscale size and ability to penetrate the skin, exosomes are ideal for topical or cutaneous applications, where they can deliver powerful regenerative signals directly to skin cells. The goal is to rejuvenate, repair, and revitalize the skin in ways we’re only beginning to fully understand.

As research evolves, lab-engineered, highly-lyophilised biomimetic exosomes mimicking human biology (designed to be as close as possible to human-derived exosomes) are paving the way for a new era in aesthetic medicine by enhancing collagen production, cellular repair, and skin revitalisation.

Once activated, lab engineered exosomes create a transformative synergy, activating the skin’s natural regenerative processes while delivering deep hydration and enhanced cellular communication.

Enhanced formulations can include plant stem cell exosomes, derived from the resilient Edelweiss plant or Ginseng plant root, both renowned for its antioxidant and anti-inflammatory properties.

Activating solutions can further reinforce the power of exosomes: hyaluronic acid molecules to ensure hydration, peptides that amplify cellular activity, antioxidants to protect against oxidative stress, and condition media packed with nutrients and growth factors to maximize the synergy between the added components.

In aesthetic medicine, exosomes have been particularly promising in correcting pigmentation issues, such as melasma, by targeting inflammation in melanocytes, the cells responsible for producing melanin at either dermal or epidermal levels. By reducing inflammation, they help modulate melanocyte activity, leading to visible improvements in pigmentation and overall skin tone.

These multifaceted properties - anti-inflammatory, antioxidant, and regenerative - make exosomes a promising tool in aesthetic and medical applications, addressing a range of conditions with precision and efficacy.

Epigenetic skin regeneration, a revolutionary approach to skincare and rejuvenation.

Epigenetics refer to the regulation of gene expression without altering the underlying DNA-sequence. In the context of skin health, this means that certain signals or factors, as those delivered by exosomes coctails
can "switch on" or "switch off" specific genes involved in repair, regeneration, and inflammation control.

Exosomes act as messengers, delivering these signals directly to target cells and triggering beneficial genetic pathways.

For example, certain exosome solutions contain bioactive molecules, peptides, and growth factors that can influence the expression of genes responsible for collagen synthesis, elastin production, and cellular renewal. This targeted activation results in a cascade of regenerative processes, helping to reverse the effects of aging, environmental stressors, and damage leading to the ageing of the skin or the hair.

The multi-faceted action of exosomes could address a wide range of skin concerns. Thanks to their epigenetic activity and unparalleled delivery system, the treatment offers remarkable outcomes for diverse dermatological and aesthetic issues.

ADDITIONAL INSIGHTS

WHAT DOES "HIGHLY LYOPHILISED" MEAN?

When we say that the exosomes are highly lyophilised, we are referring to an advanced preservation process that ensures the highest level of purity and stability. In simple terms, lyophilisation removes all water content from the exosomes, leaving them in a vacuum-packed, air-free state. This eliminates the need for refrigeration, offering more convenience and shelf stability.

The lyophilisation process not only preserves the exosomes but also ensures their remarkable purity – titrated at 99.9%, to be precise. Because exosomes are nanosized and highly concentrated, the result is a small amount of pure powder in a vial packed with billions of powerful cellular messengers ready to deliver transformative effects when reconstituted.

HIGHLY LYOPHILISED VS. LIQUID EXOSOMES

The primary difference between highly lyophilised exosomes and liquid exosome formulations lies in their stability. Lyophilised exosomes are completely free of water, vacuum-packed, and protected from air exposure. This not only ensures an exceptionally high purity (99.9%) but also eliminates the need for refrigeration, making storage and transport far easier and more reliable.

In contrast, liquid exosome formulations often require careful refrigeration or freezing to maintain their stability, as they are more prone to degradation when exposed to temperature fluctuations or environmental factors. In addition the concentrated, nanosized form ensures that a smaller amount delivers a potent effect, while their air and moisture-free state
preserves their functional integrity, ensuring they remain just as effective when reconstituted.

SYNERGY WITH ENERGY BASED DEVICES

Exosomes can work synergistically with energy-based devices, enhancing their overall effectiveness, while reducing their downtime. Exosomes are remarkably stable, maintaining their structure and function even when tested at high temperatures, as high as 80°C. This resilience ensures their compatibility with procedures involving heat or energy, such as lasers, fractional lasers, radiofrequency and RF microneedling, without compromising their therapeutic potential.

The combination of an energy-based device or technique creating absorption-channels (i.e. microneedling) with exosomes results in a powerful cumulative effect. The dual action accelerates the healing process, with potential improvements in skin texture and tone appearing almost immediately, while any post-procedural erythema significantly being reduced, achieving faster, more effective skin rejuvenation.

EXOSOMES DERIVED FROM THE STEM CELLS OF EDELWEISS FLOWER

Edelweiss, scientifically known as Leontopodium alpinum, a botanical marvel native to the rugged, high-altitude regions of the European Alps, often referred to as the "queen of the Alps," thrives in some of the harshest environments on Earth, enduring intense UV radiation, extreme cold, and nutrient-poor soils. Edelweiss is easily recognised by its distinctive star-shaped, woolly white flowers surrounded by fuzzy bracts, an endemic adaptation for own protection.

Rich in natural antioxidants as leontopodic acid and flavonoids, Edelweiss has a remarkable ability to neutralise free radicals, reduce inflammation, and protect against oxidative stress. Its anti-aging, longevity-promoting properties stem from its robust cellular mechanisms, developed over millennia survival.

EXOSOMES VERSUS POLYNUCLEOTIDES

Exosomes and polynucleotides are both promising tools in regenerative medicine, but they differ in their mechanisms and range of effects. Exosomes offer a broader spectrum of advantages due to their multifunctional nature and to the multitude of regenerative actives their cargo contains, including polynucleotides.

While polynucleotides have a single-ingredient formulation of peptides and primarily focus on skin hydration and repair as a primer, exosomes take regeneration to a cellular level.

Exosomes act as natural messengers, delivering bioactive molecules and functionalised growth factors directly to target cells.This allows them to influence a wide range of cellular activities, from reducing inflammation and controlling pigmentation to stimulating collagen and elastin production.

Polynucleotides

POLYNUCLEOTIDE SKIN BIOSTIMULATION

Polynucleotides are versatile biopolymers derived from wild salmon DNA fragments with significant applications in regenerative facial aesthetics.

Structurally, Polynucleotides are long-chain molecules made from repeating nucleotide units that function in cellular repair and regeneration. Sodium DNA is highly biocompatible, meaning it is easily accepted by human skin without triggering adverse immune responses. This makes it ideal for those looking for natural skin rejuvenation without the risks associated with synthetic chemicals.

Polynucleotides have the ability to bind large amounts of water, forming a 3D gel that enhances hydration. This hydrophilic quality, combined with their gradual enzymatic breakdown, allows Polynucleotides to sustain moisture and support cellular activity over extended periods.

In addition they act as free radical scavengers, protecting skin cells from oxidative stress, which is crucial for mitigating damage from environmental factors like UV radiation. Additionally, the activation of purinergic receptors, especially the adenosine A2A receptor, triggers anti-inflammatory responses and promotes tissue repair by inhibiting NF-kB signalling, which regulates pro-inflammatory cytokine production. As a result Polynucleotide therapy can calm the skin and reduce redness, which makes it effective for sensitive or inflamed skin.

Polynucleotides have also the ability to induce bio-stimulation, influencing fibroblast activity and collagen synthesis. They initiate cellular pathways that increase the proliferation and migration of cells like fibroblasts and endothelial cells, supporting extracellular matrix remodeling. This leads to enhanced cell turnover, improved skin texture, and reduction in fine lines and wrinkles.

In aesthetic applications, Polynucleotides enhance skin elasticity and texture, promote wound healing, and reduce signs of aging by stimulating cellular repair mechanisms and enhancing hydration. Their effects are observed in the thickening of dermal layers and restructuring of adipose tissue, which together lead to improved skin tone, reduced wrinkles, and an overall rejuvenated appearance.

Their ability to stimulate collagen and elastin production, reduce inflammation, protect against free radicals, and maintain hyaluronic acid levels makes them highly effective for long-term skin health and rejuvenation.

These properties makes skin polynucleotides a valuable addition to skin therapies focused on achieving natural, long-lasting regenerative outcomes.